Which treatment is most likely to reactivate cold sores?

Chemical peels are the most likely treatment to reactivate cold sores due to the intensity and the nature of the procedure. During a chemical peel, the application of acids can penetrate the skin and may disturb the underlying tissues, potentially leading to the reactivation of the herpes simplex virus, which is responsible for cold sores. This is particularly a concern for individuals who have a history of cold sores, as the procedure can stimulate the virus that resides in the nerve endings in the skin.

Microdermabrasion, while also an invasive treatment, tends to be less likely to trigger cold sores because it primarily exfoliates the outermost layer of the skin without penetrating deeply. Daily exfoliation may involve gentler methods that do not typically disturb the skin's deeper layers to the same extent, making them safer options for those prone to cold sores. Hydrating facial masks are generally soothing and nourishing, with minimal potential impact on the herpes virus, promoting healing and comfort instead of irritation or reactivation.